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     Practice Guidelines           
 
Singapore
Guidelines for Safe Handling of Cytotoxic Drugs
 
     Appendix
 
Procedure for donning protective clothing for preparation of chemotherapy drugs
Procedure for removing protective clothing after preparation of chemotherapy drugs
Procedure for managing cytotoxic spill 
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Resources

1) Guidelines
ISOPP Guidelines

 

2) Useful sites:
http://www.hse.gov.uk/

http://www.ashp.org/bestpractices/drugdistribution/Prep_TAB_Cytotoxic.pdf

http://www.shpa.org.au/frame.htm

http://www.osha.gov/dts/osta/otm/otm_vi/otm_vi_2.html

http://www.picscheme.org/pubs/pubs.htm

http://www.marcguidelines.com

http://pharmacy.kku.ac.th/pr/

http://www.icumed.com/Oncology.asp

 

3) Useful publications:

A case study: Surface contamination of cyclophosphamide due to working practices and cleaning procedures in two Italian hospitals.
Acampora A, Castiglia L, Miraglia N, Pieri M, Soave C, Liotti F, Sannolo N.
Ann Occup Hyg. 2005; 49:611-618.
A case study: Surface contamination of cyclophosphamide due to working practices and cleaning procedures in two Italian hospitals.
Acampora A, Castiglia L, Miraglia N, Pieri M, Soave C, Liotti F, Sannolo N.
Ann Occup Hyg. 2005; 49:611-618.
External contamination of antineoplastic drug vials.
Connor, TH.
Hosp Pharm Eur. 2005; Nov/Dec: 52-54.
Surface contamination of chemotherapy drug vials and evaluation of new vial-cleaning techniques: Results of three studies. Connor TH, Sessink PJM, Harrison BR, Pretty JR, Peters BG, Alfaro RM, Bilos
A, Beckmann G, Bing MR, Anderson LM and DeChristoforo R.
Am J Health-Syst Pharm. 2005: 62:475-484.
Handling hazardous drugs: How safe are you?
Coyle B, Polovich M.
Am J Nurs. 2004; 104:104.
Environmental contamination with cytotoxic drugs in healthcare using positive air pressure isolators.
Crauste-Manciet S, Sessink PJM, Ferrari S, Jomier J-Y, Brossard D.
Ann Occup Hyg. 2005; 49:619-628.
Biological monitoring of occupational exposure to cytostatic drugs with platinum.
Deschamps F, Marinutti-Liberge and Lamiable D.
Cancer Detect Prev Online. Available at http://www.cancerprev.org/Journal/Issues/26/101/1193/4393
Contamination of syringe plungers during the sampling of cyclophosphamide solutions.
Favier B, Gilles L, Latour JF, Desage M, Giammarile F.
J Oncol Pharm Practice. 2005; 11:1-5.
External contamination of vials containing cytotoxic agents supplied by pharmaceutical manufacturers.
Favier B, Gilles L, Ardiet C and Latour JF.
J Oncol Pharm Practice. 2003; 9:15-20.
Safety considerations and safe handling of oral chemotherapy agents.
Griffin E.
Clin J Oncol Nurs. 2003; S7:25-29.
Permeation of cytotoxic formulations through swatches from selected medical gloves.
Klein M, Lambov N, Samev N and Carstens G.
Am J Health-Syst Pharm. 2003; 1006-1011.
Chemotherapy-handling practices of outpatient and office-based oncology nurses.
Martin S.
Onc Nurs Forum. 2003; 30:575-581.
NIOSH Alert: Preventing occupational exposures to antineoplastic and other hazardous drugs in health care settings
DHHS (NIOSH) Pub No. 2004-165, September 2004.
Chemotherapy and biotherapy guidelines and recommendations for practice (2nd. ed.)
Polovich M, White J M and Kelleher LO
Pittsburgh, PA: Oncology Nursing Society.2005 Edition.
Monitoring surface contamination by antineoplastic drugs using gas chromatography-mass spectrometry and voltammetry.
Schmaus G, Schierl R and Funck S.
Am J Health-Syst Pharm. 2002; 59:956-961.
Antineoplastic agent workplace contamination study: the Alberta Cancer Board Pharmacy perspective.
Schulz H, Bigelow S, Dobish R, Chambers CR.
J Oncol Pharm Practice. 2005; 11:101-109.
Determining sources of workplace contamination with antineoplastic drugs and comparing conventional IV drug preparation with a closed system.
Spivey S and Connor TH.
Hosp Pharm. 2003; 38:135-139.
Comparative contamination study with cyclophosphamide, fluorouracil and ifosfamide: standard technique versus a proprietary closed-handling system.
Tans B and Willems L.
J Oncol Pharm Practice. 2004; 10:217-223.
Using a closed-system protective device to reduce personnel exposure to antineoplastic agents.
Wick C, Slawson MH, Jorgenson JA and Tyler LS.
Am J Health-Syst Pharm. 2003; 60:2314-2320.
Monitoring exposures of cytostatics on the hospital ward: Measuring surface contamination of four different cytotostatic drugs from one wipe sample.
Zeedijk M, Greijdanus B, Steenstra FB and Uges DRA.
Eur J Hosp Pharm. 2005; 1:18-22.
Safe handling of hazardous drugs.
Polovich M.
Online Journal of Issues in Nursing. 2004; 9 (3)Manuscript 5. Available at www.nursingworld.org/ojin/topic25/tpc25_5.htm
ASHP Guidelines on handling hazardous drugs.
Pre-publication version available at
http://www.ashp.org/bestpractices/new/HD-Prepub-final.pdf
External Contamination of Cytotoxic Drug Vials
Peter Gilbar
Journal of Pharmacy Practice and Research Vol 35. No. 4, 2005.

4) Archive
APOPC Materials

 

5) 3rd Asia Pacific Oncology Pharmacy Congress

  Day 1
DHILLON Harbans FACILITIES APOPC2010
KAUR Birinder Training2010
NG Hui Cheng QA & Audit
NG Vin Cci CML APOPC
Ngim Sharon APOPC2010_2
PARK AeRyoung Significant papers in oncology(MM)-AeRyoung Park
  Day 2
CHANTHAWONG Suthan APOPC Lung topic 2010
Lees J (to publish) Safe handling of oral anticancer agentsJLees APOPC2010
SHIH Vivianne Lunch Symposium CINV
Subongkot Suphat ASCO2010_Final_Update
VANDENBROUCKE Johan apoc 2010-07
Wong Yuet Peng Clinical Updates in Paediatric BMT
WU Tuck Seng Robotics in Oncology (08.07.10)
YEOH Ting Ting APOPC
  Day 3
ANDALUSIA Rizka APOPC Sing 2010
CHEW Lita Looking beyond 2010_ APOPC2010 ver2
Kamonsak Regional_Update_from_Thailand
ONG Simon CRC Lecture-Amended-Simon Ong

 

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